Greenhouse-grown sweet pepper is an important crop in the Region of Murcia with more of 1,700 ha. The use of grafting could be an effective tool to control soil-borne diseases such as Phytophthora spp. and Meloidogyne incognita, common in this area. The aim of this work was to study the economic viability and profitability of greenhouse-grown pepper using the grafting technique. Sweet pepper cultivar "Herminio" F₁ was grafted onto three commercial rootstocks: Atlante, Terrano and Creonte. Ungrafted "Herminio" plants were planted in biodisinfected soil with 4.5 kg·m² of fresh sheep manure and chicken manure (2:1, w/w), and non-biodisinfected soil. The production was monitored and economically evaluated according to the average prices from Ministerio de Agricultura, Alimentación y Medio Ambiente (MAGRAMA) from 2004 to 2014. The results were analyzed by Monte Carlo methodology. Grafted plants increased marketable yields (even with higher production costs), and ungrafted plants resulted in almost zero profits in disinfected soil and negative profits in non-disinfected soil. The sensitivity analysis with Monte Carlo method showed positive results in more than 95% in grafted varieties, while no more than 10% in ungrafted plants in disinfected soil, and only 1% in ungrafted plants in non-disinfected soil. In conclusion, the rootstock not only provided resistance against nematodes, but also increased crop production and therefore the profitability.